m.c acquired red cell aplasia
severe, transient, hypoplastic anemia, mc age 6mo-3yr, usually >12mo age.
Lab
- reticulocytopenia
- mod-sev normocytic anemia
- thrombocytosis
- normal MCV, HbF, eADA
Treatment
- virtually all children recover in 1-2 months
- severe anemia-B.T
- if >1 transfusion needed, re-evaluate diagnosis
- No role of corticosteroid
Diamond Blackfan vs TEC
| Feature | DBA | TEC |
|---|---|---|
| M:F | 1:1 | 1:3 |
| Mean age | 10mo | 26mo |
| Hemoglobin (g/dL) | 1.2-14.8 | 2.2-12.5 |
| WBCs < 5,000/µL | 15% | 20% |
| Platelets >400,000/µL | 20% | 45% |
| Adenosine deaminase | Increased | Normal |
| MCV increased at diagnosis | 80% | 5% |
| MCV increased during recovery | 100% | 90% |
| MCV increased in remission | 100% | 0% |
| HbF increased at diagnosis | 100% | 20% |
| HbF increased during recovery | 100% | 100% |
| HbF increased in remission | 85% | 0% |
| i Antigen increased | 100% | 20% |
| i Antigen increased during recovery | 100% | 60% |
| i Antigen increased in remission | 90% | 0% |